Non Obstructive Azoospermia & Infertility

Two-thirds of azoospermic patients have non-obstructive azoospermia (NOA); the latter comprises up to 10% of infertile men overall.

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Non Obstructive Azoospermia & Infertility

8 Mins
Updated on:
February 21, 2023
Topic:
Male Infertility
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Non Obstructive Azoospermia & Infertility

What is Non-Obstructive Azoospermia?

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The lack of sperm cells in the ejaculate is known as azoospermia. It is divided into roughly 60% Non-obstructive Azoospermia (NOA) cases and 40% Obstructive Azoospermia cases (OA).Non-Obstructive Azoospermia (NOA) is a medical disorder in which spermatogenesis fails and a man is unable to make sperm. One of the most severe types of male infertility is this one.

Why does Non-Obstructive Azoospermia (NOA) occur?

NOA can occur for a variety of reasons:Hormonal imbalances: A disorder like NOA might be brought on by a hormonal deficit,issues with the genes and chromosomes.Testicular failure occurs when there is insufficient generation of sperm because there are insufficient germ cells in the testes.Maturation arrest is the absence of the final stages of the biological process known as spermatogenesis, which produces mature, motile sperm cells from early-stage cells.

What impact does this illness have on fertility?

Non-Obstructive Azoospermia is a condition in which a male is unable to produce sperm. The couple cannot conceive naturally as a result. The ICSI procedure allows doctors to remove healthy sperm from the testicles and utilise them to fertilise the egg following a combination of effective medical and surgical procedures.

How can this issue be identified?

The primary test for diagnosis is sperm analysis. In azoospermia, no sperm are present.To determine the causes and establish a treatment plan, additional investigations such hormone tests, chromosomal analysis (Karyotype and Yq microdeletions), and testicular ultrasonography are helpful.

Is NOA treatable in any way?

NOA is treated with a combination of surgical intervention and medication, including hormone therapy. The surgical methods for removing sperm from the testes directly are called TESE and Micro-TESE. ICSI fertility treatments will assist the couple in fertilising the eggs and obtaining the embryos once the sperm have been located.

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