What is PGD / PGS
Pre-Implantation Genetic Diagnosis (PGD) and Pre-Implantation Genetic Screening (PGS) are procedures used to test IVF embryos for genetic abnormalities, chromosomal disorders or familial diseases. A few cells are removed from the embryo and the genetic material within the cells is analyzed. This supports the selection of the embryos that have the best chance for successful pregnancy.
PGD and PGS is an option for couples who have an increased risk of passing on genetic disorders and/or who are carriers of conditions such as cystic fibrosis, Duchenne Muscular atrophy, Huntington Disease, hereditary cancer syndrome (BRCA1 & 2) and other specific genetic conditions including single gene disorders, sickle cell and sex-linked diseases like hemophilia.
Couples who have familial history of genetic disorders are advised to see our Geneticist for counselling before determining whether to go for PGD/ PGS testing. PGD testing is specific to the family and requires DNA samples from the couple and also family members in some cases.
Benefits of PGD/PGS
- Embryos can be tested for a wide range of genetic, chromosomal disorders
- Couples can choose whether to do the embryo transfer and continue with the pregnancy
Note: PGD / PGS testing cannot completely eliminate the risk of disorders.
Who would benefit from PGD/PGS testing
- Couples where either partner is a carrier of genetic disorders or has strong familial evidence of genetic disorders
- Women over the age of 35 could be at risk for embryos with abnormal chromosome numbers.
- Women with high number of miscarriages (including IVF related)