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ICSI & PICSI – Advanced Sperm Selection Techniques for Enhanced Fertility Outcomes

At Jananam Fertility Centre, we offer cutting-edge fertility treatments designed to maximize the chances of conception for couples facing male infertility challenges. Intracytoplasmic Sperm Injection (ICSI) and Physiological Intracytoplasmic Sperm Injection (PICSI) are advanced sperm selection techniques used in In-Vitro Fertilization (IVF) to improve fertilization rates and embryo quality.

By integrating state-of-the-art technology with personalized patient care, we ensure that every couple has the best possible chance of achieving a successful pregnancy.

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Understanding ICSI and PICSI – Key Differences

ICSI (Intracytoplasmic Sperm Injection)

ICSI is an advanced form of IVF where a single sperm is directly injected into a mature egg under a high-powered microscope. This method bypasses natural fertilization barriers, making it particularly beneficial for men with sperm-related issues.

  • Oligospermia: Extremely low sperm count
  • Asthenospermia: Poor sperm motility
  • Teratospermia: Abnormal sperm morphology
  • Fertilization Issue: Sperm cannot penetrate the egg naturally
  • IVF Failure: Previous cycles failed due to fertilization issues
  • Surgical Sperm Retrieval: PESA/TESE due to azoospermia

PICSI is an advanced version of ICSI that mimics natural sperm selection by choosing sperm based on their ability to bind with hyaluronic acid (HA), a substance found in the egg’s outer layer. This ensures only mature, genetically stable sperm are used, improving embryo quality and implantation success.

PICSI is beneficial for:
  • Couples with recurrent pregnancy loss due to poor sperm quality.
  • Men with high sperm DNA fragmentation, which can cause embryo development issues.
  • Cases where previous IVF cycles resulted in poor embryo quality.
  • Unexplained infertility, where traditional methods have not worked.
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ICSI vs. PICSI

ICSI vs. PICSI – A Detailed Comparison

Feature ICSI (Intracytoplasmic Sperm Injection) PICSI (Physiological ICSI)
Sperm Selection Method Randomly selected under a microscope Selected based on hyaluronic acid (HA) binding, mimicking natural selection
Best for Male infertility (low sperm count, motility, or abnormal shape) Couples with recurrent pregnancy loss, poor embryo quality, or high sperm DNA fragmentation.
Risk of Genetic Abnormalities May use immature or DNA-damaged sperm Reduces risk by selecting genetically stable sperm
Success Rate 50–70% fertilization rate per cycle Higher implantation success, lower miscarriage rate
Who Should Consider? Couples with male infertility, failed IVF cycles, or surgical sperm retrieval Couples with multiple IVF failures, poor embryo quality, or unexplained infertility

Who Should Consider ICSI & PICSI?

These techniques are ideal for couples experiencing:

  • Severe Male Factor Infertility – Including low sperm count, poor motility, or abnormal sperm morphology.
  • Unexplained Infertility – When standard fertility tests do not reveal a clear reason for conception difficulties.
  • Previous IVF Failures – When conventional IVF cycles have not resulted in fertilization.
  • Use of Surgically Retrieved Sperm – In cases where sperm is obtained via TESE (Testicular Sperm Extraction) or PESA (Percutaneous Epididymal Sperm Aspiration).
  • Recurrent Pregnancy Loss – When miscarriage is linked to poor sperm selection and genetic abnormalities.
  • Egg Freezing & Fertility Preservation – When high-quality sperm selection is necessary for optimal embryo freezing outcomes.
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How to Prepare for ICSI/PICSI Treatment

ICSI (Intracytoplasmic Sperm Injection)

Proper preparation can significantly impact the success of ICSI/PICSI cycles. Here are some important steps:

  • Maintain a healthy diet rich in antioxidants, folic acid, and protein.
  • Reduce stress levels through yoga, meditation, or counseling.
  • Avoid smoking, alcohol, and excessive caffeine intake.
  • Ensure hormone levels are balanced through necessary medications.

  • Consume zinc, selenium, and vitamin C-rich foods to improve sperm health.
  • Maintain an active lifestyle but avoid excessive heat exposure (e.g., hot tubs, saunas).
  • Reduce alcohol and tobacco consumption, as they affect sperm quality.
  • Get tested for sperm DNA fragmentation, if required.
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ICSI & PICSI Process

  • Semen Analysis – Evaluating sperm count, motility, morphology, and DNA fragmentation.
  • Ovarian Reserve Testing – Checking the quantity and quality of eggs.
  • Hormonal & Genetic Testing (if necessary).

  • The female partner receives hormone injections to stimulate multiple egg production.
  • Ultrasound scans and blood tests track follicular growth.
  • An HCG trigger injection is given when the eggs are ready.

  • A minimally invasive ultrasound-guided procedure is performed under mild sedation.
  • The collected eggs are transferred to our state-of-the-art embryology lab.

  • ICSI: Sperm is randomly selected under a high-magnification microscope.
  • PICSI: Sperm are tested for their ability to bind to hyaluronic acid, ensuring only mature, healthy sperm are chosen.

  • The selected sperm is injected into the egg, and the fertilized embryos are cultured for 3 to 5 days.
  • AI-powered time-lapse embryo monitoring helps select the best-quality embryos.

  • A high-quality embryo is transferred into the uterus using a fine catheter.
  • The procedure is painless and requires no anesthesia.

  • Patients can resume normal activities with minor restrictions
  • A pregnancy test is conducted after 12–14 days to confirm the outcome.

Post-Treatment Care & Lifestyle Changes

  • Follow doctor’s advice on medications to support implantation.
  • Avoid heavy lifting or strenuous exercise for a few weeks.
  • Focus on a balanced diet rich in proteins, whole grains, and leafy greens.
  • Get adequate rest and avoid stress, as mental health impacts fertility outcomes.
  • Engage in light physical activity like walking to improve blood circulation.

Success Rates of ICSI & PICSI

  • Age of the woman – Women under 35 have better success rates.
  • Sperm Quality – High-motility sperm improve embryo development.
  • Uterine Receptivity – A healthy endometrium increases implantation chances.
  • Underlying Fertility Conditions – Conditions like PCOS, endometriosis, and genetic issues can influence outcomes.

At Jananam Fertility Centre, we use AI-based embryo grading, blastocyst culture, and advanced sperm selection techniques to improve the success rate of IVF with ICSI/PICSI.

Why Choose Jananam Fertility Centre for ICSI & PICSI?

  • Advanced IVF Lab
  • Experienced Fertility Specialists
  • Ethical & Transparent Approach
  • Compassionate Support

Take the Next Step in Your Fertility Journey

If you’re considering ICSI/PICSI, let Jananam Fertility Centre guide you with compassion, expertise, and cutting-edge reproductive technology.

What our patients say...

Jananam Fertility Centre
4.9
Based on 1210 reviews
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Ankita Paul
09:32 26 Feb 25
This place is magical. Once you step in, you will know how positive the ambience and people are. Everybody from Doctors, to nurses, to reception Ma'am, Pharmacy guy, finance & Billing team, and not to forget our food team and building guards are incredibly polite, supportive and humble.I got success in my first attempt itself. Their charges are also economical and line of treatment is very simple. They won't put you in a loop and charge unnecessarily so please be rest assured that you are in safe hands.Dr. Vani and her team is experienced and always there to support you during and after your treatment. I really wish all the women who want to conceive, please go to Dr. Vani once. In my case, Fate played an important role in making me come here but I would like to recommend this place to everyone who is going through any fertility challenge. Stay blessed and positive.They have accommodation facility also available so in case you are from different city, you don't need to worry about anything. Just leave your worries outside and enter with positivity, rest everything will be taken care by Dr. and her team. You will not see any fancy billboards or advertisements about this clinic because Jananam is known for their work and results and not the branding.I am truly thankful to Jananam for everything.
Priyanga Arul
14:48 25 Feb 25
The treatment you gave me, Iam four months pregnant, thanking you Dr.Vani madam and staff
Hindumathi TK
12:13 21 Feb 25
Hi AllThis is our second visit to Jananam for our next baby.Due to age constraints, we were little afraid on the possibility of pregnancy.But, Again Jananam made it possible for us. I'm in my 5th month now and Thanks a Million to Dr.Vani Mam and all others who supported usFirst Review:Mark my Words. Jananam is the Final and Successful destination for childless couples.You would not have even heard of this Fertility Center, as there is no much advertisements as compared to others.But they are doing THE BEST JOB, silently with great hospitalityWe after trying multiple doctors and treatments, ended up at Jananam after seeing Google Reviews.I seriously have lost all my hope of child bearing in these 7 years of my marriage life facing failures only in any of my treatments.And it was diagnosed to be Unexplained Infertility! Hope you all know how it hurts!!!Thought of giving a last try at Jananam with no idea, except the positive Google Reviews.To our surprise, now I'm 12 weeks Pregnant :)We started our treatment on March 2021, and May 7th was MY DAY, When Dr. Vani Mam announced, it was a good and healthy pregnancy!!!I bow to Dr.Vani Mam, Dr. Mangalam Mam and Dr. Prema Mam, who were supportive and kind hearted.And our Special Thanks to the Sisters and Lab Technicians, who guided as throughout the treatment process without any mess.Also a special mention to the Receptionist, Billing person and the entire team for their prompt responses for our queries.Last but not least, they are doing excellent without any interruptions even during this corona pandemic times.Thank You Jananam!!! :)
raji software
09:20 21 Feb 25
Hi this is Rajeswari Arunchakkaravarthi. I am very happy and greatful to write this review.I am one of the old patient of Jananam. I have been doing my ivf from 2016.My 1st experience in Jananam was amazing and easy. Dr. vani mam was one of the greatest Doctor and kindest human being I have met.She will treat us in very smooth and polite way, v can ask all our doubts, she'll answer it very kindly. Even all nurses and staffs are very friendly and helping. Canteen persons and food was also very good and healthy.I stayed in Jananam for 3 full months. It feeled like staying in my home.Rooms were very clean and tidy,bathroom was so hygienic.Food was on time,tasty and healthy.I have saw many fertility center, but Jananam was the only place I can trust.By God's grace and Dr. Vani mams help I conceived on 2024.now I am 4months pregnant. We are very thankful and greatful to Dr. vani mam and whole Jananam team. I strongly recommend Jananam fertility center,the one stop solution for all ur fertility problems.
Safana Ameen
17:58 18 Feb 25
Hello, iam one of the patients among Jananam Fertility Centre (way to find our dream). Becoming a mother is one of the biggest dreams for every women. I was married for 6 years and still couldn't become a parent. Underwent so many treatment procedures in many different hospitals. Finally approached Jananam referred by one of our relatives and consulted Dr.Vani. Jananam is the place where every patient can be treated specifically special and their protocols and care after every procedures are worthy which eventually helps ppl to achieve their dream of becoming parents. Their advance treatment procedures and their effective responses for our doubts and their hospitality makes us warm and comfortable and also provide us with a strong confidence. Dr.Vani is the best doctor in treating infertility problems and also in counselling the patients and helping them to build confidence and hope within themselves. Nurses also respond politely and patiently anytime whenever we approach. Even the billing team and reception ppl also help patients, in their own way. Thanks to Dr.Vani Sundarapandian and her team for helping us to become what we desired for.
Daphne Jonathaan
17:40 15 Feb 25
My experience at Jananam hospital has been overwhelmingly positive.From the moment I walked in, I felt welcomed and supported by the compassionate staff and Nurses.Dr.Vani mam is incredibly knowledgeable and took the time to explain everything clearly, answering all my questions with patience and understanding.The nurses are truly exceptional; they are kind, caring, and always went above and beyond to make me feel comfortable. The facilities are modern and clean, creating a calming and reassuring environment. Navigating fertility treatment can be a challenging journey, but Jananam hospital has made it so much easier with their expertise and genuine care. I highly recommend this hospital to anyone seeking fertility treatment; they are truly dedicated to helping their patients achieve their dreams.I am extending my heartfelt thanks Dr. Vani mam who works really hard to make our dreams come true.
Dhakshnamoorthy J
07:03 22 Jan 25
'Jananam ' takes the best care, which actually made us feel like 'home'. Jananam was referred to us by a really great doctor from a big reputed health care centre, the strong recommendation for Jananam & Dr. Vani mam was immense.Jananam proved us how true it is. The way they care, replaced our fear into trust. Each and every steps were observed & performed by the main doctor, Dr. Vani mam itself. The procedure, the cost and everything is so transparent & not money minded at all. The warmth and the care the entire environment provide is such a bliss. Dr. Vani Mam's welcoming smile has flewed away our worries and she is so reachable for all the doubts. All the sisters and the working staffs (Anju, Yuvarani, Shaija, Aishwarya, Rebina, Tosmi, Parvin, Suguna,Karuthammal, Danalakshmi, Sineka, Yuvashree, Nithyanandan) are very approachable & kind to us. For every call we made to reception and to the sisters was immediately addressed and soughted out.Anybody who is reading this review and expecting for your little miracle to happen, please step in Jananam, Dr.Vani mam will guide you with exactly what you want & the entire Jananam will hold hands and help you to attain your little miracle happen.
Asha Tara
03:10 15 Jan 25
My husband and I visited Jananam in May 2024 with lots of hopes. Dr. Vani was very friendly and knowledgeable in providing us with right recommendations. The nurses were very diligent and helpful in setting up subsequent meetings and follow ups. Overall, we returned with complete happiness. Jananam has played a very important role in our life.
Geetha Mani
09:39 04 Jan 25
We were suggested Jananam Fertility Centre by a close friend of mine and We can't thank her enough. Dr Vani Mam is a Fertility medicine expert with splendid clinical acumen. She was quick to identify the possible obstacles in our journey to parenthood and suggest the best possible treatment. We are ever grateful to her for initiating us into the joy of pregnancy. I would like to add that she prescribes only the very necessary investigations and medications, maintaining high standards and ethics.The entire place has very positive vibes putting us at ease. All sisters are quick and kind in responding to our queries always with a smile. The reception staff help us fix and maintain appointments smoothly. The billing section staff, financial counsellor, lab staff, pharmacist all work in splendid coordination avoiding any stress for us. This also contributes to the shorter waiting times. They have a canteen above providing safe, tasty and affordable food. The entire place is neat and tidy thanks to the housekeeping staff.As someone who has undergone the stress associated with multiple cycles of fertility treatment we would definitely recommend Jananam for anyone longing for parenthood. This place and the people instill us with hope and work with us right from the first visit.
kishore kumar babu
11:19 01 Jan 25
I recently visited Jananam Fertility center to seek treatment for fertility-related issues, and I am pleased to share my experience.The doctors at Jananam Fertility Center are highly skilled and knowledgeable. They took the time to explain the treatment options thoroughly and answered all my questions patiently. Their approach was reassuring and compassionate, which made the entire process less stressful.The nursing staff and administrative team were exceptionally supportive. They were approachable, attentive, and ensured that I was comfortable throughout the process.The hospital maintained transparency in terms of treatment plans, expected outcomes, and costs. There were no hidden charges, and everything was explained upfront.The hospital environment was clean, hygienic, and welcoming. It felt less like a medical facility and more like a place of hope.Over all, I highly recommend Jananam Fertility Center to anyone seeking fertility treatment. They combine expertise, care, and state-of-the-art facilities to ensure the best possible outcomes. We are very grateful to Dr Vani and entire team of Jananam fertility centre for making our life so meaningful.Rating: ⭐⭐⭐⭐⭐ (5/5)Feel free to adjust based on your specific experience!
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