Intrauterine Insemination Treatment(IUI)

IUI Treatment

What is Intrauterine Insemination (IUI)?

IUI treatment or Intrauterine Insemination and it is one of the commonest infertility treatment performed in fertility centres. The IUI treatment success rate ranges between 8 – 12% and can increase with multiple attempts to 25-30%.

There are certain causes of infertility which point towards an IUI procedure:

  • Unexplained infertility of longer than 2 years duration
  • Where the male has a slight deficit in seminal parameters
  • In couples who have a sexual dysfunction
  • The male partner has no sperm or has Azoospermia
  • When the couple have chosen donor IUI
  • The female partner has mild and minimal Endometriosis
  • The female partner has Polycystic Ovarian Syndrome
  •  Completed a few cycles of ovulation induction with timed intercourse which have not worked
  • There are certain prerequisites for an IUI process to be performed in a fertility clinic:

  • The first is the woman needs to be capable of producing an egg
  • The man needs to have a total motile sperm count, which is a calculation we make of over 5 million sperm
  •  At least one of the Fallopian tubes need to be open or patent
  • To know more about the IUI treatment cost, you can check our pricing page.

    The Procedure:

    We start stimulation on Day 2 with usually oral medication. This is to encourage the growth of follicles and follicles are fluid filled sacs within which the egg is contained.

    We monitor the growth of these follicles and after a few days, we may add a few injections or Gonadotropin injections to make the follicles grow bigger.

    Once the follicles have reached the desired size, then we plan the trigger injection. The trigger injection causes the follicle or follicles to rupture and release the egg. And this occurs about 36 hours after the trigger injection.

    After 36 hours, we plan for IUI. We collect sperms from the husband and wash the sperms so as to remove dead sperm and debris. And place or inject very gently actively motile sperm into the uterine cavity. So this helps to increase the chance of a pregnancy.

    Success Rate:

    Regarding the success rate of IUI, at best it is about 10 to 12% per cycle and when performed for 3 cycles continuously, it may go up-to 25-30%. Usually we do about 3 or 4 cycles, and if it hasn’t worked then we move into IVF Treatment and it tends to work better in younger women.

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IUI Journey

  • Consultation

    Detailed Consultation with Our Medical Director on the Course of Treatment.

  • Stimulation

    Medication (Tablet and injections will stimulate) to encourage follicular growth.

  • Scans

    Regular Scans and blood test allow us to Monitor Follicular Growth.

  • Trigger Shot

    Lead to the Maturing of the Eggs and Sets up Ovulation in the IUI Treatment.

  • Scan

    Scan Confirmation of Follicular Rupture After 36-42 Hours.

  • Sperm Collection

    Sperms are Selected and Prepared for Insemination in the IUI Treatment.

  • Insemination

    Collected Sperms are Placed in the Uterus for Insemination.


When is the best timing for an IUI?

IUI is usually done anytime between 24 hours to 40 hours from the time of administration of the trigger.

What is the highest sperm count required for IUI?

Total motile sperm count of 5 million and above is preferred for an IUI.

Before moving on to IVF, how many IUI should I try?

It can be considered only on a case to case basis depending upon the ovarian reserve, age and sperm count. Usually the norm is 4 – 6 but sometimes less numbers are advised based on the above factors.

Should I take it easy after an IUI?

Having undergone an IUI doesn’t impose any restrictions on every day routine apart from avoiding strenuous workouts if it’s part of routine.

What does an IUI feel like?

Most women experience a painless procedure. It can be compared to getting a pap smear done. The catheter used for IUI is a very thin. The discomfort or cramp is usually transient.

Where is the sperm collected?

Usually, the collection of semen sample will be done in the hospital. Once the semen sample is collected, the process of sperm washing may take anytime between 45 minutes to 2 hours.

Is IUI painful?

IUI is not a painful procedure. Some women may feel a mild discomfort or cramp but that is transient.

Can IUI be done at home?

No, this can only be done under a medical setup.

What is the kind of monitoring done for an IUI cycle?

The growth of follicle(s) will be monitored throughout by serialized scans and once the follicles reach the appropriate size, injection for rupturing of the follicles will be administrated. And the IUI procedure will be done post confirmation of the rupture.

How successful is IUI?

The success rate of IUI lies in between 8 – 12%. In IUI, the wasted and densely concentrated sperm sample is put inside the uterus. The rest of the events intended to result in pregnancy cannot be controlled.

When there is not a sperm count problem, does IUI make sense?

Sometimes, IUI will be done even if the sperm count is normal like in cases of unexplained infertility and post failure of timed intercourse.

What are the risks involved in IUI?

IUI per say does not impose any risk to the patient.

What size of follicles is considered mature?

1.8 – 2.4 cm is considered normal.

After an IUI, is bleeding common?

It’s not common, and it can happen occasionally, if there is an inflammation or erosion on the cervix which is the mouth of the uterus.

Before and after the medication, can I take pain medication?

Post rupture of the follicles, there might be pain for some women and in this instance medication such as Paracetamol can be taken. NSAID like Brufen are better avoided.

What does sperm washing mean?

Sperm washing procedure is usually done prior to the IUI by which sperms are separated from the seminal fluid.

After tubule ligation i.e. having tubes tied, does IUI work?

IUI can only be performed if one of the tubes are patent or indicated.

How long does washed sperm live?

The washed sperm can live up to 24 – 72 hours.

After an IUI, how soon can I go swimming?

Swimming is not contraindication, however it’s best avoided on the day of the IUI.

After tubal ligation i.e. having “tubes tied”, does IUI work?

IUI cannot be done post tubal ligation as the meeting between the sperms and egg requires at least one patent tube.

When is the best timing for an IUI?

Usually, the collection of semen sample will be done in the hospital. Once the semen sample is collected, the process of sperm washing may take anytime between 45 minutes to 2 hours.

Are there any tests necessary before deciding to do IUI?


For Female – Tests for ovarian reserve

                         Day 2 Baseline scan


                         Tests for Tubal Patency

Male – Seminal fluid analysis

Does IUI cause any kind of discomfort?

There can be occasional craps post IUI but usually IUI as such will not be painful.

Is Bleeding Common After an IUI?

Bleeding sometimes post IUI can happen when the speculum that is inserted comes in contact with inflamed/eroded cervical lips.

How Many Infertility Treatment Cycles Should be Done with IUI?

Generally 4 cycles of IUI are recommended. Sometimes number of cycles preferred could be less depending on the ovarian reserve and seminal parameters.

When is IUI recommended?

IUI is recommended in cases of unexplained infertility, poor seminal parameters and when 4-6 timed intercourse cycles have failed.

How do I know if I am a good candidate for IUI?

Candidates for IUI would be those couples with adequate and patent tubes and a total motile sperm count greater than 5 million.


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